Medical

Modular Biosensor Patch

Researchers are identifying new biomarkers to help monitor cognition and stress in the human body and enhance human performance. Traditional biomarkers like heart rate, temperature, oxygen partial pressure, blood glucose, electrolyte concentration, and others have been correlated with cognition and stress states. However, the correlation is indirect. Molecular biomarkers with stronger and more specific links are preferred.

Posted in: Briefs, Aerospace, Defense, Fluid Handling, MEMs, Medical, Patient Monitoring, Biosensors, Data Acquisition, Detectors, Sensors
Read More >>

Validation of Automated Prediction of Blood Product Needs Algorithm Processing Continuous Non-Invasive Vital Signs Streams (ONPOINT4)

Hemorrhagic shock occurs frequently in natural and man-made disaster scenarios. To control bleeding and to provide necessary resuscitation, swift and accurate diagnosis and decision-making are required. Early recognition of bleeding and the need for targeted interventions could improve both survival and resource management, allowing the receiving hospital to prepare required blood, surgeons, or other resources in advance of patient arrival and to conserve valuable resources in those patients who are not bleeding. Resources can be saved through avoidance of over-triage, thereby reducing unnecessary air transport, unnecessary blood transfusions, and unnecessary evaluation with labs, X-rays, and computed tomography scans, which is important in all resource-constrained and austere environments.

Posted in: Briefs, Aerospace, Data Acquisition, Defense, Industrial Controls & Automation, Manufacturing & Prototyping, Diagnostics, Patient Monitoring, Data Acquisition, Sensors
Read More >>

Blast-Induced Acceleration in a Shock Tube

High-fidelity simulation of blast flow conditions can aid in developing strategies to mitigate blast-induced brain injury.

The prevalence of blast-induced traumatic brain injury (bTBI) has prompted an urgent need to develop improved mitigation strategies and advance medical care targeting casualties with bTBI. Despite considerable effort, the basic mechanisms of blast-induced brain injury are still undefined. Based largely upon computational modeling, several candidate mechanisms of nonimpact bTBI have been identified and include head acceleration. This work hypothesizes that explosion flow conditions can cause head acceleration sufficient to injure the brain, and that these inertial forces combine with other injury mechanisms to yield bTBI.

Posted in: Briefs, Aerospace, Defense, Medical, Computer simulation, Diagnosis, Medical equipment and supplies, Head injuries, Occupant protection
Read More >>

Wireless Vital Signs Monitor for Trauma Patients

A miniature, portable wireless vital signs monitor (MWVSM), called Mini-medic™, could aid in the triage and diagnosis of trauma patients with and without traumatic brain injury (TBI). The MWVSM consists of two components, both of which are the approximate size and weight of a cellphone: one is a sensor that is placed either on the forehead or the fingertip of a patient, and the other is a monitor that receives a wireless signal transmitted up to 100 m carried by the medic.

Posted in: Briefs, Aerospace, Defense, Medical, Sensors and actuators, Medical, health, and wellness, Head injuries
Read More >>

Effect of Acceleration Frequency on Spatial Orientation Mechanisms

Extreme motion environments can induce loss of visual acuity, motion sickness, and spatial disorientation. Understanding how human sensory integration of acceleration stimuli affects spatial awareness will improve models of spatial disorientation and mishap analysis. While there are numerous studies describing vestibular semicircular canal responses to angular acceleration, less is known about vestibular otolith responses to linear acceleration. This gap in knowledge is important to resolve, since seasickness and airsickness are highly dependent on the predominant frequency of a linear acceleration stimulus.

Posted in: Briefs, Medical, Body regions, Human factors, Nervous system, Vehicle acceleration, Vehicle dynamics
Read More >>

Precision Targeting with a Tracking Adaptive Optics Scanning Laser Ophthalmoscope

Adaptive optics (AO) has become increasingly utilized in research ophthalmic diagnostic instruments since their first use nearly ten years ago. Integration of adaptive optics in scanning laser ophthalmoscopy (SLO) is a flying-spot technique whereby scattered light in images is blocked by placement of an aperture at a back conjugate focal plane. Adaptive optics systems sense perturbations in the detected wavefront and apply corrections to an optical element that flattens the wavefront and allows near diffraction-limited focus.

Posted in: Briefs, Medical, Adaptive control, Lasers, Medical equipment and supplies
Read More >>

High-Resolution Anatomic and Elastographic Transrectal Ultrasound for Improved Diagnosis of Prostate Cancer

Prostate cancer screening generally uses the Pro state Spe cific Antigen (PSA) blood test, free-PSA testing, and Digital Rectal Exam ination (DRE). When the PSA is used, there exists a significant gray area in which cancers may be missed. Addition ally, DRE is practically limited to the detection of shallow (subcapsular) palpable abnormalities. Even systematic multi-core biopsy fails to detect clinically detectable cancers in up to 34% of men. Thus, there is compelling clinical interest in finding improved detection methods.

Posted in: Briefs, Medical, Diagnosis, Diseases, Physical examination, Acoustics, Test equipment and instrumentation
Read More >>

Macromolecular Carriers for Nanomedicine and Nano Devices

Tailoring the surface properties of biodegradable nanospheres and microspheres for in-vivo blood-contacting applications includes defining relationships among chemical composition, processing parameters, nanosphere sizes and size distributions, and surface structure. Developments include: 1) a facile method for achieving magnetite-polylactide nanospheres that can be dispersed in aqueous media; 2) methods for functionalizing the termini of the hydrophilic brushes on the nanospheres in order to conjugate targeting moieties; 3) development of a nanosphere processing approach that yields nanospheres in the desired size range with a narrow distribution of sizes; and 4) maintainence of all of these characteristics with up to approximately 60 weight percent of magnetite incorporated into the nanospheres.

Posted in: Briefs, Medical
Read More >>

Genetic Studies of Responses of Bones to Mechanical Stresses

Progress has been reported in a continuing program of molecular genetic studies of the responses of bones to mechanical stresses. Prior studies in mice and humans had provided evidence that mechanical loading stimulates bone formation and that immobilization or loss of mechanical stimulation leads to decreasing bone formation and increasing bone loss. Other prior studies in humans and mice had demonstrated that bone anabolic response differs widely among individuals subjected to the same degree of mechanical loading. The initiation of the present studies was motivated by the conjecture that variations in bone anabolic response among individuals are attributable to differences in the transcription levels of genes; that is, they are genetically controlled.

Posted in: Briefs, Medical
Read More >>

Tactical Medical Coordination System

The term "tactical medical coordination system" (TacMedCS) denotes any of several prototype electronic systems for tracking patients in a scenario that may involve multiple instances of treatment by different medical personnel in different locations. The TacMedCS was conceived as a means of facilitating coordination of care of military personnel injured in combat and/or facilitating coordination of care of victims of large-scale disasters. The most advanced prototype has already been demonstrated to be effective in operations at a Navy fleet hospital.

Posted in: Briefs, Medical
Read More >>